This paper provides an in-depth literature review on the dyadic function of couples with cancer. Specifically, the literature review will explore: (a) the impact of cancer on romantic relationship quality and stability, (b) the biopsychosocial-spiritual correlates of cancer and their connections to romantic relationship quality and stability, and (c) the recommendations for future study and implications for couple therapists working with couples facing cancer. Additionally, we present a detailed examination of relevant theoretical foundations for working with couples with cancer. First, the biopsychosocial-spiritual (BPSS) framework, and second, the Vulnerability-Stress-Adaptation (VSA) model, are examined. Combined, these two theoretical approaches offer a comprehensive foundation for examining the relationships of romantic couples with cancer. The paper concludes with recommendations and implications for couple therapists, with the hope of helping couples with cancer find higher levels of quality and stability in their romantic relationships. [ABSTRACT FROM AUTHOR]