This study was designed to evaluate the effects of dietary crawfish shell meal (CSM) on the growth performance, digestive enzyme activity and anti‐oxidative capacity of Oujiang color common carp. 180 juvenile fish (initial weight 3.0 ± 0.5 g) were assigned to the control group and the CSM25 group (fed with 25% substitution of fish meal by CSM) for 8 weeks. Results showed that significant improvement in the weight gain rate (WGR) in CSM25 group than the control (p <.05), whereas no significant change in feed conversion ratio, specific growth rate and feeding intake between the groups (p >.05). Also, no significant difference was obsevered between the groups in terms of serum biochemical index and muscle composition (p >.05). And liver superoxide dismutase, catalase, glutathione peroxidase (GPx), lysozyme (LYZ) and protease activities in CSM25 group were significantly higher (p <.05). Moreover, histological analysis indicated that width of mucosa and thickness of muscular coat in mid‐intestine were significantly changed (p <.05). In conclusion, dietary supplement with CSM25 induced high oxidative stress, promote protease activities and had no negative effects on the growth performance of Oujiang color common carp. Hence, CSM may be a viable alternative protein source to reduce the demand for fish meal. [ABSTRACT FROM AUTHOR]