There are limited treatments for severe COVID-19; of the empirical treatments used in this study (dexamethasone, remdesivir, convalescent plasma), the only dexamethasone is associated with reduced 28-day mortality in the general population [[3]-[5]]. Herein, we highlight our experience of using remdesivir and convalescent plasma to treat persistent symptomatic COVID-19 in a patient with secondary immunodeficiency following long-term rituximab treatment. To the Editor, We read with interest the report from London et al. regarding the efficacy of convalescent plasma in the treatment of severe COVID-19 in two patients with primary immunodeficiencies [[1]]. The efficacy of convalescent plasma in the treatment of COVID-19 in patients has been reported in small case series of individuals with both congenital and acquired B cell aplasia [[7]-[9]]. [Extracted from the article]