Oral mucositis after tacrolimus/sirolimus or cyclosporine/methotrexate as graft‐versus‐host disease prophylaxis.
- Resource Type
- Article
- Authors
- Garming Legert, Karin; Ringdén, Olle; Remberger, Mats; Törlén, Johan; Mattsson, Jonas; Dahllöf, Göran
- Source
- Oral Diseases. Jul2021, Vol. 27 Issue 5, p1217-1225. 9p. 1 Diagram, 3 Charts, 1 Graph.
- Subject
- *GRAFT versus host disease prevention
*STOMATITIS
*RAPAMYCIN
*TIME
*CONVALESCENCE
*CYCLOSPORINE
*METHOTREXATE
*SEVERITY of illness index
*HEMATOPOIETIC stem cell transplantation
*STATISTICAL sampling
*TACROLIMUS
- Language
- ISSN
- 1354-523X
Objectives: To determine whether treatment with tacrolimus plus sirolimus (Tac/Sir) as a prophylaxis for graft‐versus‐host disease worsens severe oral mucositis and delays healing compared to cyclosporine plus methotrexate (CsA/Mtx) following haematopoietic stem cell transplantation. Subjects and Methods: The study comprised 141 patients: 73 randomized to receive Tac/Sir and 68 to receive CsA/Mtx. The oral mucositis assessment scale and toxicity grading according to WHO were used to assess the severity, peak and duration of oral mucositis from the day −3 to day 24 post‐transplant. Results: Eighty‐seven patients developed oral mucositis in the first 24 days post‐transplant. No significant difference in oral mucositis severity between the Tac/Sir and CsA/Mtx groups was observed. The peak oral mucositis score occurred on day 10 in both groups. Although oral mucositis scores had returned to baseline in the CsA/Mtx group on day 24 post‐transplant, no significant difference compared with the Tac/Sir group was found. Conclusions: The introduction of tacrolimus/sirolimus as a graft‐versus‐host disease prophylaxis in haematopoietic stem cell transplantation increased neither the incidence nor severity of oral mucositis compared with cyclosporine/methotrexate. Furthermore, oral mucositis healing was not prolonged and followed the same time pattern as cyclosporine/methotrexate. [ABSTRACT FROM AUTHOR]