(G) Proposed model depicting regulation and role of NRF2/miR-125b-1 in APL gl Together, our data demonstrate that miR-125b-1 expression is likely due to PML-RAR -mediated NRF2 activity, thus explaining the elevated miR-125b-1 in primary APL samples. NRF2 activation induced by PML-RAR promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia The fact that chemotherapy sustainably increases NRF2/miR-125b-1 levels prompted us to test the impact of NRF2/miR-125b-1 on response to chemotherapy. Also, ROS-generating NADPH oxidase (NOX2 complex) gene expression was decreased in miR-125b-overexpressing NB4 cells and APL patients, and overexpression of miR-125b could increase the level of NRF2 in APL cells (Figures 4A and S6A-S6C). [Extracted from the article]