WNT-Regulated Transcriptional Enhancers and Stem Cell Plasticity.
- Resource Type
- Article
- Authors
- Mirzadeh Azad, Fatemeh; Atlasi, Yaser
- Source
- Trends in Cell Biology. Jul2021, Vol. 31 Issue 7, p525-528. 4p.
- Subject
- *STEM cells
*WNT signal transduction
*CELLULAR control mechanisms
*CANCER stem cells
- Language
- ISSN
- 0962-8924
Enhancer reprogramming lies at the heart of dynamic cellular processes such as differentiation and tumorigenesis. WNT signaling is an evolutionary conserved pathway that exploits transcriptional enhancers to control the state-specific transcriptional program. Recent evidences suggest several mechanisms that govern this state-specific enhancer regulation in stem cells and cancer. [ABSTRACT FROM AUTHOR]