A genetic variation in CHI3L1 is associated with bronchial asthma.
- Resource Type
- Article
- Authors
- Shao, Jinlian; Yang, Xuexi; Ren, Dunqiang; Luo, Yaling; Lai, Wenyan
- Source
- Archives of Physiology & Biochemistry. Jun2021, Vol. 127 Issue 3, p279-284. 6p.
- Subject
- *GENETIC variation
*ASTHMA
*ASTHMATICS
*CHINESE people
*SINGLE nucleotide polymorphisms
*WHEEZE
- Language
- ISSN
- 1381-3455
This study was aimed to investigate the associations among Chitinase 3-like 1 (CHI3L1) polymorphisms, asthma and plasma YKL-40 levels in Chinese population. Four CHI3L1 single nucleotide polymorphisms (SNPs) were genotyped. The YKL-40 level in plasma and eosinophil percentage in peripheral blood were quantified. A SNP (rs4950928) in the CHI3L1 promoter was associated with elevated plasma YKL-40 levels (p =.02), asthma (p =.042) and lung function (p =.029 to.002) in this Chinese population. Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects (p <.05). Plasma YKL-40 levels were significantly correlated with forced expiratory volume per cent (FEV1%) measurements (p <.05). Although plasma YKL-40 levels were decreased after treatment, the correlation with FEV1% still existed. CHI3L1 locus is a risk factor for asthma in Chinese population. [ABSTRACT FROM AUTHOR]