Synthesis of Chiral o -Aminobenzylamines by Stereoselective Addition of Grignard Reagents to N -[(o -Aminophenyl)methylene] sulfinamides.
- Resource Type
- Article
- Authors
- Zhong, Xianqiang; Xiao, Guorong; Zhou, Wei
- Source
- Synlett. 2021, Vol. 32 Issue 10, p1019-1023. 5p.
- Subject
- *GRIGNARD reagents
*SULFINAMIDES
*ASYMMETRIC synthesis
- Language
- ISSN
- 0936-5214
Chiral o-aminobenzylamines are synthons for many chiral ligands and catalysts that have been widely used in asymmetric synthesis. Here, we report a highly efficient and stereoselective addition of Grignard reagents to N -[(o -aminophenyl)methylene]sulfinamides to give a range of o -aminosulfinylimines in good yields with good to excellent diastereoselectivities. [ABSTRACT FROM AUTHOR]