Regioselective Direct C2 Arylation of Indole, Benzothiophene and Benzofuran: Utilization of Reusable Pd NPs and NHC-Pd@MNPs Catalyst for C–H Activation Reaction.
- Resource Type
- Article
- Authors
- Hegde, Rajeev V.; Ong, Tiow-Gan; Ambre, Ram; Jadhav, Arvind H.; Patil, Siddappa A.; Dateer, Ramesh B.
- Source
- Catalysis Letters. May2021, Vol. 151 Issue 5, p1397-1405. 9p.
- Subject
- *ARYLATION
*BENZOFURAN
*CATALYSTS
*HETEROGENEOUS catalysis
*BENZOFURANS
*INDOLE compounds
*INDOLE
- Language
- ISSN
- 1011-372X
A regioselective C2 arylation of indoles, benzothiophene and benzofuran without directing group has been accomplished using economically cheap Pd NPs and NHC-Pd@MNPs catalyst. The reusable catalyst is efficiently employed to access C2 arylated heterocycles in good to excellent yield. The reusability of the catalyst is studied up to five cycles and a gram-scale synthesis has been achieved. The reaction mechanism is well supported by control experiments and literature precedents. [ABSTRACT FROM AUTHOR]