Rhodium‐Catalyzed Synthesis of Chiral Monohydrosilanes by Intramolecular C−H Functionalization of Dihydrosilanes.
- Resource Type
- Article
- Authors
- Ma, Wenpeng; Liu, Li‐Chuan; An, Kun; He, Tao; He, Wei
- Source
- Angewandte Chemie. 2/19/2021, Vol. 133 Issue 8, p4291-4297. 7p.
- Subject
- *CLASS B metals
*STEREOCHEMISTRY
- Language
- ISSN
- 0044-8249
The preparation of chiral monohydrosilanes remains a rarely achieved goal. To this end a Rh‐catalyzed desymmetrization of dihydrosilanes by way of intramolecular C(sp2)−H functionalization under simple and mild conditions has now been developed. This method provides easy access to a broad range of chiral monohydrosilanes in good yields with excellent enantioselectivities (up to >99 % ee). The resulting monohydrosilanes constitute a good platform to access stereogenic silicon compounds, as well as useful compounds to probe silicon stereochemistry. [ABSTRACT FROM AUTHOR]