Scutellaria barbata Leaf Extract Mediated Gold Nanoparticles for Alzheimer's Disease Treatment by Metal-Induced Amyloid β Aggregation Inhibition.
- Resource Type
- Article
- Authors
- Wang, Guoqing; Dai, Jingcun; Lu, Xinjian
- Source
- Journal of Cluster Science. Nov2020, Vol. 31 Issue 6, p1269-1273. 5p.
- Subject
- *SCUTELLARIA
*ALZHEIMER'S disease
*THERAPEUTICS
*AMYLOID
*GOLD nanoparticles
*STABILIZING agents
*REDUCING agents
- Language
- ISSN
- 1040-7278
In this work, we have synthesized gold nanoparticles (AuNPs) using flavonoids of Scutellaria barbata as reducing and stabilizing agent. The prepared AuNPs were studied by using various spectroscopic and microscopic techniques. TEM analysis showed the formation of 20 nm sized spherical nanoparticles. XRD analysis confirmed the formation of crystalline face centred cubic structured particles. Further, we studied the as prepared AuNPs for their efficiency to act as a novel class of amyloid-β (Aβ) inhibitors. The results showed that several small and relatively amorphous aggregates validated the exceptional efficiency of AuNPs in inhibiting Aβ40 aggregation. Therefore, the prepared AuNPs has future prosperous towards the treatment of Alzheimer's disease. [ABSTRACT FROM AUTHOR]