Context: Developing low-cost assessment tools to quantify ankle biomechanics in a clinical setting may improve rehabilitation for patients with chronic ankle instability (CAI). Objective: To determine whether a crossline laser can predict peak plantar pressure during walking. Design: Descriptive laboratory study. Setting: Laboratory. Patients or other participants: Twenty-five participants with CAI (9 men, 16 women; age = 20.8 ± 2.3 years, height = 170.4 ± 10.4 cm, mass = 78.9 ± 22.4 kg). Intervention(s): Participants completed 30 seconds of treadmill walking with a crossline laser fixed to their shoe while, simultaneously, a video camera recorded the laser projection on the wall and an in-shoe plantar-pressure system measured plantar pressure. Main outcome measure(s): Peak laser rotation and peak plantar pressure of the lateral midfoot and forefoot. Results: With respect to peak plantar pressure, peak rotation of the laser during walking explained 57% of the variance in the lateral midfoot and 64% in the lateral forefoot. Conclusions: The crossline laser may be a valuable clinical tool for predicting lateral peak plantar pressure in patients with CAI during walking. [ABSTRACT FROM AUTHOR]