Next-generation sequencing has revolutionized oncology, with determination of cancer genetic profiles leading to precision medicine for the management and treatment of oncology patients. Ultrasound-guided liver core needle biopsy performed at an outside hospital showed a tumor with trabecular and vaguely gland-forming architecture. In this case, neuroendocrine IHC was not performed initially, and the tumor molecular profile with I MEN1 i and I ATRX i alterations combined with wild-type I APC i , I KRAS i , and I TP53 i prompted suspicion of a neuroendocrine neoplasm rather than a colorectal adenocarcinoma. [Extracted from the article]