Ineffectual Type 2-to-Type 1 Alveolar Epithelial Cell Differentiation in Idiopathic Pulmonary Fibrosis: Persistence of the KRT8hi Transitional State.
- Resource Type
- letter
- Authors
- Peng Jiang; Gil de Rubio, Rafael; Hrycaj, Steven M.; Gurczynski, Stephen J.; Riemondy, Kent A.; Moore, Bethany B.; Omary, M. Bishr; Ridge, Karen M.; Zemans, Rachel L.; Jiang, Peng
- Source
- American Journal of Respiratory & Critical Care Medicine; 6/1/2020, Vol. 201 Issue 11, p1443-1447, 5p
- Subject
- EPITHELIAL cells
IDIOPATHIC pulmonary fibrosis
TRANSFORMING growth factors-beta
RNA sequencing
REGENERATION (Biology)
- Language
- ISSN
- 1073449X
The article focuses on type 2 alveolar epithelial cells (AEC2s) proliferate and then differentiate into AEC1s to restore normal alveolar architecture and function. It mentions Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease that arises from ineffectual regeneration of the injured epithelium and unchecked TGF-beta (transforming growth factor beta) signaling. It also mentions single-cell RNA sequencing study of lineage-labeled AEC2s during physiologic regeneration.