Structure, Absolute Configuration and Biological Evaluation of a New Labdane Diterpenoid from Jatropha podagrica.
- Resource Type
- Article
- Authors
- Dongbo Zhang; Jingao Yu; Zhen Zhang; Yanni Liang; Zhishu Tang; Zheng Wang
- Source
- Records of Natural Products. Sep/Oct2020, Vol. 14 Issue 5, p355-360. 6p. 3 Diagrams, 1 Chart.
- Subject
- *JATROPHA
*SCHISANDRA
*NITRIC oxide
*MACROPHAGES
- Language
- ISSN
- 1307-6167
Jatrodagricaine A (1), a new labdane-type diterpenoid, together with three known derivatives (2-4) were isolated from the leaves of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods. The absolute configuration of 1 was established by its biosynthetic pathway and comparison to known compound. All compounds were investigated for their anti-inflammatory and thioredoxin reductase (TrxR) inhibitory activities. Compound 1 showed potential inhibition in terms of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with IC50 value of 40.6 ± 2.2 µM. [ABSTRACT FROM AUTHOR]