Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia: What Nurses Need to Know.
- Resource Type
- Article
- Authors
- Fidler, Kristen M.
- Source
- Pediatric Nursing; Mar/Apr2020, Vol. 46 Issue 2, p64-69, 6p, 2 Charts
- Subject
- Families
Continuing education of nurses
Patient education
Continuing education units
Blood
Cardiovascular system
Gastrointestinal system
Genitourinary organs
Glucocorticoids
Musculoskeletal system
Pediatric nursing
Respiratory organs
Skin
Dexamethasone
Early diagnosis
Retinoic acid syndrome
Disease risk factors
Symptoms
- Language
- ISSN
- 00979805
Differentiation syndrome (DS) is a life-threatening complication specific to patients with acute promyelocytic leukemia (APL) receiving all-trans retinoic acid (ATRA) or arsenic trioxide (ATO) during induction therapy. These agents have significantly improved complete remission rates and overall survival rates in pediatric patients. However, approximately one-quarter of patients receiving ATRA or ATO develop DS, which can lead to progressive cardiorespiratory distress and multiple organ failure. Early recognition and prompt initiation of systemic steroids have dramatically reduced the morbidity and mortality associated with this complication. The pediatric nurse is at the front line of patient care and plays a significant role in optimizing outcomes for these patients. [ABSTRACT FROM AUTHOR]