Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium.
- Resource Type
- Article
- Authors
- Manion, Maura; Dimitrova, Dimana; Pei, Luxin; Gea-Banacloche, Juan; Zelazny, Adrian; Lisco, Andrea; Zerbe, Christa; Freeman, Alexandra F; Holland, Steven M; Kanakry, Christopher G; Kanakry, Jennifer A; Sereti, Irini
- Source
- Clinical Infectious Diseases. 2/15/2020, Vol. 70 Issue 4, p676-679. 4p.
- Subject
- *BIOMARKERS
*BONE marrow transplantation
*MYCOBACTERIAL diseases
*MYCOBACTERIUM avium
*IMMUNE reconstitution inflammatory syndrome
*DISEASE complications
- Language
- ISSN
- 1058-4838
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers. [ABSTRACT FROM AUTHOR]