Antigen-specific T-cell lines transfer protective immunity against Trichinella spiralis in vivo.
- Resource Type
- Article
- Authors
- Riedlinger, J.; Grencis, R. K.; Wakelin, D.
- Source
- Immunology. May86, Vol. 58 Issue 1, p57-61. 5p.
- Subject
- *T cells
*ANTIGENS
*IMMUNITY
*TRICHINELLA spiralis
*MAST cell disease
*EOSINOPHILIA
- Language
- ISSN
- 0019-2805
T-cell lines specific for infective muscle larvae antigens of the intestinal nematode Trichinella spiralis have been generated in vitro. These antigen-specific T-cell lines express the L3T4+ Ly2- phenotype and secrete the lymphokines IL-2, IL-3 and γ-IFN. They are stable in culture for up to 15 weeks and are protective when adoptively transferred into naive recipients. As few as 2 × 105 T. spiralis-specific T cells have the capacity to accelerate the expulsion of a challenge infection from the gastrointestinal tract. In addition, intestinal mastocytosis and peripheral blood eosinophilia were accelerated after adoptive transfer of T. spiralis-specific T-cell lines. [ABSTRACT FROM AUTHOR]