Lymphocyte emperipolesis revisited 1. DEVELOPMENT OF IN VITRO ASSAY AND PRELIMINARY CHARACTERISATION OF THE LYMPHOCYTE SUBPOPULATION INVOLVED.
- Resource Type
- Article
- Authors
- Sandilands, G. P.; Reid, Fiona M.; Gray, Kathleen G.; Anderson, J. R.
- Source
- Immunology. Aug78, Vol. 35 Issue 2, p381-389. 9p.
- Subject
- *LYMPHOCYTES
*LIVER cells
*FC receptors
*T cells
*IMMUNOLOGY
- Language
- ISSN
- 0019-2805
A surprisingly high proportion of antibody (IgG) sensitized Chang liver ceils apparently contained one or more intracytoplasmic human peripheral blood lymphocytes following a period of contact at 37°. Since various technical factors were found to influence this phenomenon of lymphocyte ‘emperipolesis’, optimum conditions were selected for use in a standard quantitative in vitro assay. Lymphocytes from normal individuals varied considerably in their ability to participate in emperipolesis; an observation which suggested that a particular lymphocyte subpopulation may be involved, Preliminary characterization of emperipoletic cells indicated that they are Fc receptor bearing, non-T lymphocytes. The significance of these findings in relation to immune mechanisms is discussed. [ABSTRACT FROM AUTHOR]