The physio-chemical properties of natural bone are significantly determined by the biological environment. Thus, it is desirable to prepare advanced bone tissue engineered scaffold by mimicking nature bone formation process. In this study, we proposed a new simple method (physio-chemical mixing) to prepare a hybrid hydroxyapatite (HA) scaffolds mimicking nature bone. Nano powder phases constitution was studied by SEM, XRD, and TEM. The results founded that the simple method could affect the physio-chemical properties (i.e., compositions and morphologies) of HA scaffolds. Moreover, the scaffolds prepared could have mimicked the nature bone. [ABSTRACT FROM AUTHOR]