A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay.
- Resource Type
- Article
- Authors
- Liu, Zhichao; Wu, Peicong; Yin, Yaoyao; Tian, Yang
- Source
- Chemical Communications. 8/28/2019, Vol. 55 Issue 67, p9955-9958. 4p.
- Subject
- *ADENOSINE triphosphate
*CEREBROSPINAL fluid
*ALZHEIMER'S disease
*DNA
- Language
- ISSN
- 1359-7345
A silver nanocluster-based ratiometric fluorescent nanosensor was developed for the determination of ATP in the cerebrospinal fluid of a mouse brain. Using this useful tool with good stability and high selectivity as well as a wide linear detection range, it was found that the ATP concentration in a mouse brain with Alzheimer's disease was 2300-fold higher than that in a normal one. [ABSTRACT FROM AUTHOR]