Embryonic self-fracking.
- Resource Type
- Article
- Authors
- Arroyo, Marino, ; Trepat, Xavier,
- Source
- Science; 8/2/2019, Vol. 365 Issue 6452, p442-443, 2p, 1 Diagram
- Subject
- Mammalian embryos
Cell junctions
Contractility (Biology)
Blastocyst
Cell communication
- Language
- ISSN
- 00368075
The article examines how mammalian embryos use controlled hydraulic fracturing to sculpt their shape. It mentions that the mouse embryo self-fractures by pressurizing fluid between cell-cell junctions to establish its first symmetry axis and coarsening of the resulting microlumens is then precisely directed by spatially modulating cytoskeletal contractility and thus cellular surface tension. It also mentions about performing of live imaging of the formation of the blastocyst.