Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts.
- Resource Type
- Article
- Authors
- Mayya, Viveka; Judokusumo, Edward; Abu-Shah, Enas; Neiswanger, Willie; Sachar, Chirag; Depoil, David; Kam, Lance C.; Dustin, Michael L.
- Source
- Journal of Immunology. 8/1/2019, Vol. 203 Issue 3, p601-606. 6p.
- Subject
- *T cells
*COMPETITIVE advantage in business
*SYNAPSES
*MEMORY
*CELL populations
*ORIGINAL sin
*PSYCHONEUROIMMUNOLOGY
- Language
- ISSN
- 0022-1767
Memory T cells are endowed with multiple functional features that enable them to be more protective than naive T cells against infectious threats. It is not known if memory cells have a higher synapse propensity (SP; i.e., increased probability to form immature immunological synapses that then provide an entry into different modes of durable interaction with APCs). In this study, we show that only human memory CD8 T cells have remarkably high SP compared with naive counterparts. Such a dichotomy between naive and memory cells is not observed within the human CD4 or murine CD8 T cell population. Higher SP in human memory CD8 T cells allows them to outcompete and prevent naive CD8 T cells from getting recruited to the response. This observation has implications for original antigenic sin and aging of the immune system in humans. [ABSTRACT FROM AUTHOR]