The aim of this work was to compare the frying stability of refined olive pomace oil alone and blended with refined coconut oil during 60 successive sessions. Frying experiments were carried out at 180 °C and samples were evaluated by high-performance size-exclusion chromatography (HPSEC), measuring the polymers and polar compounds formed. The tocopherol content was also analyzed. At the end of the frying process, the lowest content of polymeric compounds (PC) and total polar compounds (TPC) were detected for the blend of refined olive pomace oil–refined coconut oil (ROPO/RCO) with 13.20% and 25%, respectively, compared to refined olive pomace oil (ROPO) pure with 16.9% and 34.5%, respectively. Hence, the present study based on PC and TPC as best quality indicators of frying oil degradation indicated that the frying behavior of ROPO pure significantly improved by the blending application with RCO and showed a higher chemical stability. [ABSTRACT FROM AUTHOR]