Autophagy inducing cyclic peptides constructed by methionine alkylation.
- Resource Type
- Article
- Authors
- Qin, Xuan; Shi, Xiaodong; Tu, Licheng; Ma, Yue; Zhou, Ziyuan; Zhao, Rongtong; Zhan, Meimiao; Yin, Feng; Li, Zigang
- Source
- Chemical Communications. 4/14/2019, Vol. 55 Issue 29, p4198-4201. 4p.
- Subject
- *CYCLIC peptides
*ALKYLATION
*METHIONINE
*PEPTIDES
- Language
- ISSN
- 1359-7345
Peptides that induced autophagy at micromolar concentrations with improved proteolytic resistance properties were generated using the facile methionine bis-alkylation method. Notably, a short bicyclic peptide 7f was proven to be the most potent one among the designed peptides in regards to autophagy inducing activity. This study facilitated the development of a peptide-based autophagy inducer and demonstrated the potential applications of the methionine alkylation-based macrocyclization method for the diversity-oriented generation of peptide-based autophagy inducers. [ABSTRACT FROM AUTHOR]