Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.
- Resource Type
- journal article
- Authors
- Guan, Wenda; Yang, Zifeng; Wu, Nicholas C; Lee, Horace H Y; Li, Yimin; Jiang, Wenxin; Shen, Lihan; Wu, Douglas C; Chen, Rongchang; Zhong, Nanshan; Wilson, Ian A; Peiris, Malik; Mok, Chris K P
- Source
- Journal of Infectious Diseases. 10/15/2018, Vol. 218 Issue 8, p1238-1248. 11p.
- Subject
- *INFLUENZA A virus, H7N9 subtype
*VIRUS diseases
*RESPIRATORY infections
*GENE expression
*INFLUENZA viruses
- Language
- ISSN
- 0022-1899
Background: Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.Methods: We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.Results: We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.Conclusions: We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection. [ABSTRACT FROM AUTHOR]