Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017.
- Resource Type
- Article
- Authors
- Xu, Yufan; Peng, Xiaorong; Peng, Xiuming; Ji, Shujing; Chen, Bin; Wang, Liyan; Lu, Xiangyun; Xie, Tiansheng; Sun, Tao; Wang, Hui; Wu, Nanping
- Source
- Archives of Virology. Aug2018, Vol. 163 Issue 8, p2233-2237. 5p.
- Subject
- *HIV-positive persons
*DRUG resistance
*ANTIVIRAL agents
*PHYLOGENY
*GENOTYPES
- Language
- ISSN
- 0304-8608
In recent years, transmitted drug resistance (TDR) has adversely impacted upon first-line therapy for HIV-infected individuals. To understand the current subtype distribution and TDR level in Zhejiang, China we performed phylogenetic analysis and genotypic drug resistance testing of treatment-naive HIV-infected individuals. A total of 153 HIV-1 Pol genes were successfully amplified. The distribution of HIV-1 genotypes was as follows: CRF01_AE (43.8%); CRF07_BC (37.9%); subtype B/B’ (7.2%); CRF08_BC (5.2%); and others (5.9%). Drug resistance analysis demonstrated that 11.1% of isolates contained at least one NRTI or NNRTI resistance-associated mutations while 2.0% were identified to be resistant to PIs. These findings enhance our understanding of the genetic diversity of HIV-1 strains circulating in Zhejiang and provide some guidelines for HIV initial treatment therapy. [ABSTRACT FROM AUTHOR]