Synthesis of functionalized pyrroloindolines via a visible-light-induced radical cascade reaction: rapid synthesis of (±)-flustraminol B.
- Resource Type
- Article
- Authors
- Wu, Kui; Du, Yuliu; Wei, Zheng; Wang, Ting
- Source
- Chemical Communications. 7/11/2018, Vol. 54 Issue 54, p7443-7446. 4p.
- Subject
- *INDOLINE
*ALLYL alcohol
*CHEMICAL synthesis
- Language
- ISSN
- 1359-7345
The development of visible-light-induced synthesis of functionalized pyrroloindolines via a radical cascade reaction is reported. The reaction shows a broad substrate scope and highlights the mild nature of the reaction conditions. A range of substitutions on indole aromatic rings and N-centers is well tolerated, including a free allylic alcohol. Relying on the strategy, a rapid synthesis of (±)-flustraminol B was achieved. [ABSTRACT FROM AUTHOR]