A series of novel arylpyrazole derivatives containing aminomethanephosphonate and phenylfuran moieties were designed, synthesized and characterized by1H NMR,31P NMR and IR spectroscopy and elemental analyses. The single crystal structure of diethyl [5-(4-chlorophenyl)furan-2-yl][3-cyano-1-(2,3,4-trifluorophenyl)-1H-pyrazol-5-ylamino]methanephosphonate (4l) was determined by X-ray diffraction. Preliminary bioassays showed that these phosphonates exhibit satisfactory insecticidal activities againstCulexpipiensandMusca domesticaat 0.1%. In particular, compound4lexhibited a most promising KT50 value, which is superior to that of Dextraltetramethrin® and similar to Prallehtrin®. The structure-activity relationship was also preliminarily investigated. [ABSTRACT FROM AUTHOR]