The existence of a putative post-transcriptional regulatory element in 3′-UTR of drosophila antibacterial peptide diptericin’s mRNA
- Resource Type
- Article
- Authors
- Chen, Hai-xu; Li, Yue; Jiang, Zhao-zhao; Qu, Xian-ming; Yang, Sheng-li; Ma, Wei-jun
- Source
- FEBS Letters. Mar2004, Vol. 561 Issue 1-3, p181. 5p.
- Subject
- *ANTIBACTERIAL agents
*PEPTIDES
*GENETIC regulation
*MESSENGER RNA
- Language
- ISSN
- 0014-5793
Antibacterial peptides’ genes are rapidly and transiently expressed on immune stimulation, which is the characteristic of immediate early genes. It implies post-transcriptional regulation is an important pathway in antibacterial peptides’ gene expression. In a search of putative post-transcriptional regulatory elements, we found a segment of an AU-rich sequence in 3′-untranslated region (UTR) of drosophila diptericin mRNA. 3′-UTR of diptericin mRNA can be specifically bound with Elav and this binding can be competed with the typical AU-rich element (ARE) of c-fos mRNA. These results suggest that the AU-rich sequence in the 3′-UTR of diptericin mRNA may be a cis-acting element and involved in post-transcriptional regulation. [Copyright &y& Elsevier]