Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives.
- Resource Type
- Article
- Authors
- Meng, Dongmei; Tang, Yongzhen; Wei, Junfa; Shi, Xianying; Yang, Mingyu
- Source
- Chemical Communications. 5/25/2017, Vol. 53 Issue 42, p5744-5747. 4p.
- Subject
- *COPPER catalysts
*CATALYSIS
*CARBON-hydrogen bonds
*PYRROLIDINE derivatives
*AMINATION
- Language
- ISSN
- 1359-7345
We report a copper-catalyzed remote C(sp3)–H bond amination reaction that converts acyclic amines to pyrrolidines. This reaction occurs selectively at the carbon δ to the amine functionality. Primary, secondary and tertiary C–H bonds are all suitable for the amination reactions in the presence of an inexpensive and commercially available copper catalyst. [ABSTRACT FROM AUTHOR]