Eosin-5-maleimide binding to band 3 and Rh-related proteins forms the basis of a screening test for hereditary spherocytosis.
- Resource Type
- Article
- Authors
- May-Jean King, Nicholas C.; Smythe, Jonathan S.; Mushens, Rosey
- Source
- British Journal of Haematology. Jan2004, Vol. 124 Issue 1, p106-113. 8p. 3 Black and White Photographs, 3 Charts, 5 Graphs.
- Subject
- *EOSIN
*MEMBRANE proteins
*RH factor
*GLYCOPROTEINS
*CD antigens
*FLOW cytometry
- Language
- ISSN
- 0007-1048
Investigates the integral membrane proteins that react with eosin-5-maleimide (EMA) using chemical modifications. Predominant interaction of EMA; Association of molecules containing sulfhydryl groups with the Rh blood group protein complex; CD47 and the Rh-associated glycoprotein; Results of immunoprecipitation; Predictive value of the EMA binding test for hereditary spherocytosis.