An Iron(II) Chloride-Promoted Radical Cascade Methylation or α-Chloro-β-methylation of N-Arylacrylamides with Dimethyl Sulfoxide.
- Resource Type
- Article
- Authors
- Li, Zejiang; Cui, Xiaosong; Niu, Lin; Ren, Yingming; Bian, Menghua; Yang, Xuebiao; Yang, Biao; Yan, Qinqin; Zhao, Jincan
- Source
- Advanced Synthesis & Catalysis. 1/19/2017, Vol. 359 Issue 2, p246-249. 4p.
- Subject
- *CHLORIDES
*RADICALS (Chemistry)
*METHYLATION
*DIMETHYL sulfoxide
*HABER-Weiss reaction
*OXINDOLES
*CHEMICAL synthesis
- Language
- ISSN
- 1615-4150
A free radical-initiated methylation and/or α-chloro-β-methylation of N-arylacrylamides with dimethyl sulfoxide under the analogous Fenton reaction condition has been developed, which provides an effective and facile cascade strategy for the synthesis of oxindoles and chlorinated amides. [ABSTRACT FROM AUTHOR]