C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams.
- Resource Type
- Article
- Authors
- Shi, Renyi; Lu, Lijun; Xie, Hangyu; Yan, Jingwen; Zhang, Hua; Lei, Aiwen; Xu, Ting; Qi, Xiaotian; Lan, Yu
- Source
- Chemical Communications. 11/21/2016, Vol. 52 Issue 90, p13307-13310. 4p.
- Subject
- *DEALKYLATION
*CARBON-hydrogen bonds
*LACTAMS
*CHEMICAL synthesis
- Language
- ISSN
- 1359-7345
Pd-catalyzed selective amine-oriented C8–H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing group for promoting this process. It represents a straightforward and easy method to access various biologically important benzo[cd]indol-2(1H)-one derivatives. [ABSTRACT FROM AUTHOR]