OBJECTIVE: To determine the prevalence of MRSA among Staphylococci isolated from SSTI, to describe the demographic details & antimicrobial susceptibility pattern METHODS: Two years retrospective study (Jan 2011 to Dec 2012) involving 991 patients with skin and soft tissue infections was done. To evaluate the susceptibility of Staphylococcus aureus to antibiotics, the disk diffusion method and oxacillin screening agar were used. RESULTS: Out of 991 samples collected, 350 (35.3%) had positive culture for S.aureus, 245 (70%) were MRSA & 105 (30%) were Methicillin Sensitive Staphylococcus Aureus (MSSA). All the MRSA isolates were sensitive to Vancomycin & Linezolid. Sensitivity to other antibiotics were - Amikacin (80%), Chloramphenicol (78%), Tetracycline (32%), Cotrimoxazole (33%), Clindamycin (88%) and Ciprofloxacin (18%). Prevalence of MRSA was common among males (65.7%) & in the age group between 25- 55 years. Abscess (42.8%) and Diabetic foot (18.5%) were the common underlying risk factors.. CONCLUSION: High proportion of MRSA was observed in our study. This calls for formulation of specific treatment guidelines to prevent emergence of resistance to currently used drugs. [ABSTRACT FROM AUTHOR]