Autoimmunity and Primary Immunodeficiency Disorders.
- Resource Type
- Article
- Authors
- Allenspach, Eric; Torgerson, Troy
- Source
- Journal of Clinical Immunology. May2016 Supplement, Vol. 36, p57-67. 11p.
- Subject
- *AUTOIMMUNITY
*IMMUNODEFICIENCY
*NUCLEOTIDE sequencing
*IMMUNOLOGICAL tolerance
*IMMUNOLOGICAL deficiency syndromes
- Language
- ISSN
- 0271-9142
Advances in DNA sequencing technologies have led to a quickening in the pace at which new genetic immunodeficiency disorders have been identified. Among the newly identified defects are a number of disorders that present primarily with autoimmunity as opposed to recurrent infections. These 'immune dysregulation' disorders have begun to cluster together to form an increased understanding of some of the basic molecular mechanisms that underlie the establishment and maintenance of immune tolerance and the development of autoimmunity. This review will present three major themes that have emerged in our understanding of the mechanisms that underlie autoimmunity and immune dysregulation in humans. [ABSTRACT FROM AUTHOR]