Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C–H activations.
- Resource Type
- Article
- Authors
- Hu, Liang; Chen, Xiang; Gui, Qingwen; Tan, Ze; Zhu, Gangguo
- Source
- Chemical Communications. 5/21/2016, Vol. 52 Issue 41, p6845-6848. 4p.
- Subject
- *BENZAMIDE
*METHYLATION
*FUNCTIONAL groups
*CHEMICAL synthesis
*CARBON-hydrogen bonds
- Language
- ISSN
- 1359-7345
A highly mono-selective ortho-trifluoromethylation of benzamides was achieved via Cu-promoted C–H activations. The reaction employs an 8-aminoquinoline group as the bidentate directing group and Togni reagent II as the CF3 source. The reaction tolerated a wide variety of functional groups and various ortho-trifluoromethylated benzamides were efficiently synthesized in 36–82% yield. [ABSTRACT FROM AUTHOR]