Background: Understanding the impact of malnutrition on pro and anti- inflammatory cytokine response in Plasmodium falciparum (p.f) infected children is very important for malaria control. This study specifically examined the balance between Interleukin 10,TumourNecrosis Factor (TNF) and nutritional status of Plasmodium falciparum malaria infected children in South Eastern Nigeria to determine and evaluate the influence of malnutrition onimmune response among p.f Infected children in Imo State Nigeria. Methods & Materials: Ethical considerations were duly observed. Children aged 1-72 months with ongoing fever or history of fever within the last 24 hours and with no sign suggestive of severe malaria were involved in this study. Blood films stained with giemsa and rapid diagnostic test (RDT) kit were used to diagnose malaria parasitemia. Their Nutritional status was determined using the international Reference Population defined by the U.S National Center for Health Statistics (NCHS). IL-10 and TNF were assayed by ELISA. Statistical analysis was done using SPSS version 17. Results: A total of 1344 febrile chilren were involved in this study. From this group 26.3% and 31.5% were positive for malaria parasites microscopically and through the RDT kit respectively. The cytokines were associated significantly with malaria infection. IL- 10/TNF ratio was significantly associated with parasite density and age (p<0.05). IL-10/TNF ratio was lower in children 1-24 months when compared with older children. There was however no significant association between the nutritional status of these chilren and malaria infection. Non significant proportions were stunted (22.9%), Under weight (9.4%) and wasted (5.2%). Stunting, underweight and wasting cut across the study population. These findings show no significant relationship between presence of malaria and stunting, Underweight and wasting, rather stunting and wasting were associated with age (p< 0.05). There was no relationship observed between the IL-10 and TNF cytokines levels and the nutrional status of the study population. Conclusion: Findings from this study suggest that there is no association between malnutrition and malaria as well as between the nutritional status of the study population and their cytokine level. [ABSTRACT FROM AUTHOR]