Objective: To evaluate the efficacy of metformin administration throughout pregnancy on pregnancy-related complications in women with polycystic ovary syndrome (PCOS). Study design: MEDLINE and ScienceDirect were searched to retrieve relevant trials. The endpoint was the incidence of complications of pregnancy, gestational diabetes mellitus (GDM), pre-eclampsia (PE), miscarriage and premature birth included. Results: Five studies with 502 PCOS patients with metformin administration throughout pregnancy and 427 controls who used metformin just to get conception were included in our meta-analysis. In study group, a significantly lower change of emerging miscarriage and premature birth was observed, the pooled relative risk (RR) was 0.32 (95% confidence interval (CI): 0.19–0.56) for miscarriage and 0.40 (95%CI: 0.18–0.91) for premature birth. No significant difference was demonstrated in emerging GDM and PE. Conclusions: Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects. 目的:妊娠期间给予多囊卵巢综合征(PCOS)患者二甲双胍,评估二甲双胍对妊娠相关并发症的疗效。 研究设计:在MEDLINE和ScienceDirect上检索相关研究。终点为妊娠期并发症发生率,包括妊娠期糖尿病(GDM),子痫前期(PE),流产和早产。 结果:我们的meta分析包括5项共502例妊娠期间给予二甲双胍治疗的PCOS患者和427例使用二甲双胍后怀孕的对照人群。实验组观察到流产和早产率显著降低,综合后流产的相对风险(RR)为0.32(95%置信区间(CI):0.19-056),早产的RR为0.40(95%CI:0.18-0.91)。出现GDM和PE的发生率无统计学差异。 结论:妊娠期间对PCOS患者给予二甲双胍可降低流产和早产的发生率且无严重副作用。 [ABSTRACT FROM AUTHOR]