Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes.
- Resource Type
- Article
- Authors
- Lee, Wei-Chih; Chen, Chien-Hung; Liu, Cheng-Yuan; Yu, Ming-Shiuan; Lin, Yung-Huei; Ong, Tiow-Gan
- Source
- Chemical Communications. 12/14/2015, Vol. 51 Issue 96, p17104-17107. 4p.
- Subject
- *NICKEL catalysts
*PYRIDINE
*REGIOSELECTIVITY (Chemistry)
*CATALYSIS
*LIGANDS (Chemistry)
*ISOMERIZATION
- Language
- ISSN
- 1359-7345
para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis in combination with a bulkier NHC ligand and a Lewis acid, leading to linear hydroheteroarylation products. Interestingly, the branch selectivity can be achieved by using the combination of a less sterically hindered amino-NHC ligand and AlMe3 through tandem reaction of facile alkene isomerization followed by a slow CH bond activation process. [ABSTRACT FROM AUTHOR]