Tissue-Specific Replicating Capacity of a Chimeric Poliovirus That Carries the Internal Ribosome Entry Site of Hepatitis C Virus in a New Mouse Model Transgenic for the Human Poliovirus Receptor.
- Resource Type
- Article
- Authors
- Yanagiya, Akiko; Ohka, Seii; Hashida, Noriyasu; Okamura, Masahito; Taya, Choji; Kamoshita, Nobuhiko; Iwasaki, Kuniko; Sasaki, Yukari; Yonekawa, Hiromichi; Nomoto, Akio
- Source
- Journal of Virology. Oct2003, Vol. 77 Issue 19, p10479-10487. 9p. 1 Color Photograph, 1 Black and White Photograph, 2 Diagrams, 4 Graphs.
- Subject
- *POLIOVIRUS
*LIVER
*MOSAICISM
*HEPATITIS C virus
- Language
- ISSN
- 0022-538X
Demonstrates that the chimeric poliovirus (PV) replicates in the liver but not in the brain of a mouse model Tg for hPVR. Tissue-specific replicating capacity of a chimeric poliovirus that carries the internal ribosome entry site of hepatitis C virus; Virus growth in vivo and neurovirulence; Detection of hPVR in various tissues.