Inside Cover: A U⋅U Pair-to-U⋅C Pair Mutation-Induced RNA Native Structure Destabilisation and Stretching-Force-Induced RNA Misfolding (ChemPlusChem 8/2015).
- Resource Type
- Article
- Authors
- Zhong, Zhensheng; Soh, Lai Huat; Lim, Ming Hui; Chen, Gang
- Source
- ChemPlusChem. Aug2015, Vol. 80 Issue 8, p1190-1190. 1p.
- Subject
- *CHEMISTRY
*CHEMICALS
- Language
- ISSN
- 2192-6506
The cover picture shows the experimental setup for mechanical (un)folding of RNA hairpins using optical tweezers (not to scale). The contribution of a single hydrogen bond to RNA folding was directly revealed by nanomanipulation using optical tweezers. Disruption of a single hydrogen bond by the replacement of a single RNA U⋅U pair with a U⋅C pair results in an increase in the rate of mechanical unfolding and more frequent misfolding. Details are given in the Full Paper by Gang Chen et al. on page 1267. [ABSTRACT FROM AUTHOR]