Reverse Physiology: Applying an Antihypertensive Drug to Increase Arterial Blood Pressure in Septic Shock.
- Resource Type
- Editorial
- Authors
- Gradwohl-Matis, Ilse; Dünser, Martin W.
- Source
- Critical Care Medicine. Jul2015, Vol. 43 Issue 7, p1548-1550. 3p.
- Subject
- *ANTIHYPERTENSIVE agents
*SEPTIC shock
*BLOOD pressure
*ANGIOTENSIN II
*CLONIDINE
*EWES
*PATIENTS
- Language
- ISSN
- 0090-3493
The authors reflect on the study by Y. R. Lankadeva and colleagues on the use antihypertensive drugs to increase septic shock patients' arterial blood pressure. The study reportedly involved an examination of the impact of clonidine on arterial blood pressure, pressor responsiveness to phenylephrine and angiotensin II, and renal sympathetic nerve activity in ewes with mild hypotension with septic shock. The results revealed that clonidine can restore arterial pressor response to phenylephrine.