Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody.
- Resource Type
- Article
- Authors
- Tsvetkov, Lyuben; Xingzhi Xu; Jia Li; Stern, David F.
- Source
- Journal of Biological Chemistry. 3/7/2003, Vol. 278 Issue 10, p8468. 8p. 3 Color Photographs, 4 Graphs.
- Subject
- *PROTEIN kinases
*DNA damage
*CENTROSOMES
- Language
- ISSN
- 0021-9258
Describes the interaction of polo-like kinase 1 and Chk2, a protein kinase intermediary in DNA damage checkpoint pathways to centrosomes and the midbody. Inducement of phosphorylation of Chk2 due to DNA damage; Result of indirect immunofluorescence microscopy; Suggestion of lateral communication between the DNA damage and mitotic checkpoints.