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Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

Resource Type: Article
Authors: Xu, Meng; Cai, Chengfeng; Sun, Xuli; Chen, Wanze; Li, Qinxi; Zhou, Huamin
Source: Biochemical & Biophysical Research Communications. Jul2015, Vol. 463 Issue 3, p275-279. 5p.
Subject: *TUMOR necrosis factors
*CELL death
*FIBROSARCOMA
*CANCER cells
*CELLULAR signal transduction
*LABORATORY mice
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ISSN: 0006-291X

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초록

Clnk, as a third member of the Blnk/SLP-76 adapter family, is involved in the positive regulation of immunoreceptor signaling. Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells. Therefore, Clnk, as an adaptor protein, may take part in the other cellular processes. [ABSTRACT FROM AUTHOR]

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학술논문

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Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

Online Access

초록