A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyrans via double direct C–F substitutions.
- Resource Type
- Article
- Authors
- Yang, Jieru; Mao, Ao; Yue, Zhenting; Zhu, Wenxuan; Luo, Xuewei; Zhu, Chuwei; Xiao, Yuanjing; Zhang, Junliang
- Source
- Chemical Communications. 5/14/2015, Vol. 51 Issue 39, p8326-8329. 4p.
- Subject
- *PYRAN synthesis
*CARBON
*FLUORINE
*SUBSTITUTION reactions
*FLUORINATION
*MOLECULAR structure
- Language
- ISSN
- 1359-7345
A straightforward and efficient approach to structurally diverse and synthetically useful ring-fluorinated 4H-pyrans via a simple base-mediated cascade reaction of readily available trifluoromethylated alkenes with 1,3-dicarbonyl compounds was developed. The key events of this reaction involve two consecutive C–F substitutions under very mild conditions. [ABSTRACT FROM AUTHOR]