Direct synthesis of cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source.
- Resource Type
- Article
- Authors
- Li, Zheng; Zhao, Zhouxing
- Source
- Research on Chemical Intermediates. May2015, Vol. 41 Issue 5, p3147-3155. 9p. 2 Diagrams, 2 Charts.
- Subject
- *CYANOHYDRINS
*ESTERS
*CHEMICAL synthesis
*CHLORIDES
*POTASSIUM compounds
*CYANIDES
*SUSTAINABLE chemistry
- Language
- ISSN
- 0922-6168
A direct synthetic method for cyanohydrin esters from aroyl chlorides using potassium hexacyanoferrate(II) as an eco-friendly cyanide source and tributylphosphine as a promoter is described. This protocol has advantages of no use of strong toxic cyanating agents, high yield, and simple work-up procedure. [ABSTRACT FROM AUTHOR]