Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.
- Resource Type
- Article
- Authors
- Florio, Marta; Albert, Mareike; Taverna, Elena; Takashi Namba; Brandl, Holger; Lewitus, Eric; Haffner, Christiane; Sykes, Alex; Fong Kuan Wong; Peters, Jula; Guhr, Elaine; Klemroth, Sylvia; Prüfer, Kay; Kelso, Janet; Naumann, Ronald; Nüsslein, Ina; Dahl, Andreas; Lachmann, Robert; Pääbo, Svante; Huttner, Wieland B.
- Source
- Science. 3/27/2015, Vol. 347 Issue 6229, p1465-1470. 6p.
- Subject
- *NEOCORTEX
*GENES
*NEUROGLIA
*GENE expression
*LABORATORY mice
*HUMAN genetics
*HUMAN evolution
- Language
- ISSN
- 0036-8075
The article focuses on an analysis of the transcriptomes of progenitor subpopulations using a cell polarity-based approach to isolate them in developing human and mouse neocortex. It states 56 genes were identified that preferentially expressed in human apical and basal radial glia that house orthologs lacked with the gene ARHGAP11B having the highest degree of expression. It comments on the role human-specific gene ARHGAP11B may have contributed in human neocortex evolutionary expansion.