Palladium-Catalyzed Cross-Coupling between 7-Azaindoles and Reformatsky Reagents.
- Resource Type
- Article
- Authors
- Barl, Nadja M.; Malakhov, Vladimir; Mathes, Christian; Lustenberger, Philipp; Knochel, Paul
- Source
- Synthesis. 2015, Vol. 47 Issue 5, p692-700. 9p.
- Subject
- *AZAINDOLES
*REFORMATSKY reaction
*PALLADIUM catalysts
*COUPLING reactions (Chemistry)
*ARYLATION
*ESTER derivatives
*SILYL ethers
*CHEMICAL reagents
- Language
- ISSN
- 0039-7881
The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields. [ABSTRACT FROM AUTHOR]