Brønsted acid ionic liquid-catalyzed reductive Friedel–Crafts alkylation of indoles and cyclic ketones without using an external reductant.
- Resource Type
- Article
- Authors
- Taheri, Amir; Lai, Bingbing; Cheng, Cheng; Gu, Yanlong
- Source
- Green Chemistry. 2015, Vol. 17 Issue 2, p812-816. 5p.
- Subject
- *BRONSTED acids
*IONIC liquids
*FRIEDEL-Crafts reaction
*ALKYLATION
*INDOLE compounds
*KETONES
*CATALYSTS
- Language
- ISSN
- 1463-9262
In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Brønsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way. [ABSTRACT FROM AUTHOR]